The Houston Texans' 2006 NFL draft proved to be a pivotal moment in establishing the franchise's future. With the No. 1 overall pick, the Texans selected Mario Williams, a decision that ultimately paid off, as he recorded impressive stats of 53 sacks and 64 tackles for loss over six seasons. Though Williams departed due to financial constraints and scheme fit, he left an indelible mark on the team's history.

In addition to Williams, the Texans made shrewd selections in later rounds with DeMeco Ryans, who became the Defensive Rookie of the Year, and Eric Winston, who anchored the offensive line as their starting right tackle for six seasons. The acquisition of Wisconsin's Owen Daniels, who emerged as a reliable tight end, further solidified a draft class that laid the groundwork for the franchise’s first playoff appearance under head coach Gary Kubiak.